Glioblastoma multiforme gbm accounts for more than half of mg cases they are associated with high morbidity and mortality despite current multimodality treatment efforts including maximal surgical resection if feasible followed by a combination of radiotherapy and or chemotherapy the median survival is short only about 15 months. Despite advances in standard therapy including surgical resection followed by radiation and chemotherapy the prognosis for patients with glioblastoma multiforme gbm remains poor unfortunately most patients die within 2 years of diagnosis of their disease. Advances in the pathogenesis and treatment of glioblastoma multiforme michael prados pathogenesis molecular characteristics and prognostic factors for survival keith l ligon standard treatment approaches for newly diagnosed glioblastoma soon tae lee patrick y wen targeted therapeutic strategies for relapsed disease john f de . Introduction glioblastoma is the most common malignant primary brain tumor in adults and invariably carries a poor prognosis despite optimal multimodality treatment that typically includes surgery radiation and cytotoxic chemotherapy recent clinical trials have reported a median survival of only 14 16 months with a 26 33 2 year survival rate 12
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