Clozapine clozapine clz still actually the main stone of atypical antipsychotics belongs to the chemical class of the dibenzodiazepines it has many unique clinical advantages over typical neuroleptic agents including its efficacy in treatment refractory schizophrenia a low propensity to induce extrapyramidal symptoms eps particularly tardive dyskinesia and it does not increase . The pharmacokinetic and pharmacodynamic properties of raclopride a new antipsychotic were investigated in 16 healthy men hammarlund udenaes m basic pharmacokinetics of remoxipride and its influence on prolactin farde l von bahr c sedvall g pharmacodynamics and pharmacokinetics of raclopride after single oral doses in male . We also tried to simulate fi of remoxipride immediate release by the same method and the predicted fi value was 0823 which was quite close to the reported measured fi 081 see appendix 20 the results have suggested that the first order absorption one compartment model could be robust and useful to assess pk fluctuation of each
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